Although early treatment ambivalence and disengagement are not uncommon, once stabilized on buprenorphine, effective long-term recovery can be achieved. It is primarily prescribed as an oral or sublingual medication in office based primary care or addiction medicine practices, and it is increasingly being prescribed in hospitals and emergency departments to initiate therapy and bridge patients to outpatient programs. Due to the difficulties of conducting longer-term clinical trials involving patients with OUD, clinicians should consider other information sources including peer discussions from the abundant, real-time information available on Reddit.īuprenorphine is one of the most effective evidence-based treatments for opioid use disorder (OUD). Physical exercise, clonidine, and Imodium ® were frequently reported to help during the recovery process. Diarrhea, insomnia, restlessness, and fatigue were commonly reported adverse events. Based on two models, one that incorporated ‘upvoting’ by other members and one that did not, we found that Reddit users reported more successful recovery with longer tapering schedules, particularly from 2.0 mg to 0.0 mg (median: 93 days mean: 95 days), as compared to shorter tapering schedules investigated in past clinical trials. Analysis of a sample of these posts showed that 74% of the posts described users’ personal experiences and that the top three topics included advice on using Suboxone ® (55.0%), Suboxone ® dosage information (35.5%) and information about Suboxone ® tapering (32.0%). In this study, we used data-driven natural language processing methods to mine a total of 16,146 posts about buprenorphine from 1933 unique users on the anonymous social network Reddit. However, there are a limited number of conclusive scientific studies that provide guidance to medical professionals about strategies for using buprenorphine to achieve stable recovery. Medication-assisted treatment (MAT), in particular, buprenorphine and buprenorphine combination products such as Suboxone ®, is the most effective, evidence-based treatment for OUD. Over 47,000 overdose-related deaths in 2017 involved opioids. Opioid use disorder (OUD) is a public health emergency in the United States.
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